{"id":2395,"date":"2018-07-23T13:14:19","date_gmt":"2018-07-23T13:14:19","guid":{"rendered":"https:\/\/andreasphysioblog.com\/?p=2395"},"modified":"2021-06-16T20:08:01","modified_gmt":"2021-06-16T20:08:01","slug":"diagnosis-treatment-and-prevention-of-ankle-sprains-update-of-an-evidence-based-clinical-guideline","status":"publish","type":"post","link":"https:\/\/andreasphysioblog.com\/?p=2395","title":{"rendered":"Diagnosis, treatment and prevention of ankle sprains: update of an evidence-based clinical guideline"},"content":{"rendered":"<header class=\"entry-header\">\n<h1 class=\"entry-title\">Diagnosis, treatment and prevention of ankle sprains: update of an evidence-based clinical\u00a0guideline<\/h1>\n<\/header>\n<div class=\"entry-body\">\n<div class=\"entry-meta\"><\/div>\n<div class=\"entry-content\">\n<p><img decoding=\"async\" class=\"alignnone size-full wp-image-14075\" src=\"https:\/\/andreasbjerregaard.files.wordpress.com\/2018\/07\/skc3a6rmbillede-2018-07-23-kl-19-09-23.png?w=825\" sizes=\"(max-width: 825px) 100vw, 825px\" srcset=\"https:\/\/andreasbjerregaard.files.wordpress.com\/2018\/07\/skc3a6rmbillede-2018-07-23-kl-19-09-23.png?w=825 825w, https:\/\/andreasbjerregaard.files.wordpress.com\/2018\/07\/skc3a6rmbillede-2018-07-23-kl-19-09-23.png?w=150 150w, https:\/\/andreasbjerregaard.files.wordpress.com\/2018\/07\/skc3a6rmbillede-2018-07-23-kl-19-09-23.png?w=300 300w, https:\/\/andreasbjerregaard.files.wordpress.com\/2018\/07\/skc3a6rmbillede-2018-07-23-kl-19-09-23.png?w=768 768w, https:\/\/andreasbjerregaard.files.wordpress.com\/2018\/07\/skc3a6rmbillede-2018-07-23-kl-19-09-23.png?w=1024 1024w, https:\/\/andreasbjerregaard.files.wordpress.com\/2018\/07\/skc3a6rmbillede-2018-07-23-kl-19-09-23.png 1378w\" alt=\"Sk\u00e6rmbillede 2018-07-23 kl. 19.09.23\" data-attachment-id=\"14075\" data-permalink=\"https:\/\/physioblogandreasbjerregaard.com\/skaermbillede-2018-07-23-kl-19-09-23\/\" data-orig-file=\"https:\/\/andreasbjerregaard.files.wordpress.com\/2018\/07\/skc3a6rmbillede-2018-07-23-kl-19-09-23.png\" data-orig-size=\"1378,446\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"Sk\u00e6rmbillede 2018-07-23 kl. 19.09.23\" data-image-description=\"\" data-medium-file=\"https:\/\/andreasbjerregaard.files.wordpress.com\/2018\/07\/skc3a6rmbillede-2018-07-23-kl-19-09-23.png?w=300\" data-large-file=\"https:\/\/andreasbjerregaard.files.wordpress.com\/2018\/07\/skc3a6rmbillede-2018-07-23-kl-19-09-23.png?w=825\" \/><\/p>\n<p><strong>What<\/strong><\/p>\n<p>A lateral ankle sprain (LAS) is a frequently incurred musculoskeletal injury.\u00a0A large proportion of individuals who sustain a LAS will develop chronic ankle instability (CAI).\u00a0CAI may be defined as persistent complaints of pain, swelling\u00a0and\/or giving way in combination with recurrent sprains for at least 12 months after the initial ankle sprain.<\/p>\n<p><strong>Inclusion\u00a0and exclusion criteria <\/strong><\/p>\n<ul>\n<li>Inclusion if they included individuals aged at least 16 years with acute LAS. Studies published in Dutch, English, German, French, Spanish, Danish or Swedish were all eligible for inclusion.<\/li>\n<li><em>Narrative reviews, case reports and cadaveric analyses were excluded<\/em>. <em>Additional exclusion criteria were reported medial ankle involvement, fractures or other concomitant injuries\/pathology and CAI.<\/em><\/li>\n<\/ul>\n<p><strong>Results<\/strong><\/p>\n<p><img decoding=\"async\" class=\"alignnone size-full wp-image-14077\" src=\"https:\/\/andreasbjerregaard.files.wordpress.com\/2018\/07\/skc3a6rmbillede-2018-07-23-kl-19-17-01.png?w=825\" sizes=\"(max-width: 770px) 100vw, 770px\" srcset=\"https:\/\/andreasbjerregaard.files.wordpress.com\/2018\/07\/skc3a6rmbillede-2018-07-23-kl-19-17-01.png 770w, https:\/\/andreasbjerregaard.files.wordpress.com\/2018\/07\/skc3a6rmbillede-2018-07-23-kl-19-17-01.png?w=150 150w, https:\/\/andreasbjerregaard.files.wordpress.com\/2018\/07\/skc3a6rmbillede-2018-07-23-kl-19-17-01.png?w=300 300w\" alt=\"Sk\u00e6rmbillede 2018-07-23 kl. 19.17.01.png\" data-attachment-id=\"14077\" data-permalink=\"https:\/\/physioblogandreasbjerregaard.com\/2018\/07\/23\/diagnosis-treatment-and-prevention-of-ankle-sprains-update-of-an-evidence-based-clinical-guideline\/skaermbillede-2018-07-23-kl-19-17-01\/\" data-orig-file=\"https:\/\/andreasbjerregaard.files.wordpress.com\/2018\/07\/skc3a6rmbillede-2018-07-23-kl-19-17-01.png\" data-orig-size=\"770,602\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"Sk\u00e6rmbillede 2018-07-23 kl. 19.17.01\" data-image-description=\"\" data-medium-file=\"https:\/\/andreasbjerregaard.files.wordpress.com\/2018\/07\/skc3a6rmbillede-2018-07-23-kl-19-17-01.png?w=300\" data-large-file=\"https:\/\/andreasbjerregaard.files.wordpress.com\/2018\/07\/skc3a6rmbillede-2018-07-23-kl-19-17-01.png?w=770\" \/><\/p>\n<p><strong>RICE<\/strong><\/p>\n<ul>\n<li>What\u2019s new: No new statements could be made based on the newly identified studies. The increased evidence indicates that the individual aspects of RICE are not effective, apart from cryotherapy, if provided in combination with exercise therapy.<\/li>\n<li>Recommendation (modified): There is no evidence that RICE alone, or cryotherapy, or compression therapy alone has any positive influence on pain, swelling or patient function. Therefore, there is no role for RICE alone in the treatment of acute LAS (level 2)\n<ul>\n<li><em>(based on 33 randomized controlled trials (RCTs), n=2337)<\/em><\/li>\n<\/ul>\n<\/li>\n<\/ul>\n<p><strong>NSAID<\/strong><\/p>\n<ul>\n<li>What\u2019s new: Based on the search results concerning treatment, the committee agreed on implementing a topic on NSAIDs. Over the past years much research has been undertaken on NSAIDs in relation to musculoskeletal injuries, and in many countries they are available without prescription. However, before recommending NSAIDs, their effect in the specific context of an ankle sprain had to be assessed.<\/li>\n<li>Recommendation (new): NSAIDs may be used by patients who have incurred an acute LAS for the primary purpose of reducing pain and swelling. However, care should be taken in NSAID usage as it is associated with complications (level 2) and may suppress or delay the natural healing process.<\/li>\n<\/ul>\n<p><strong>Immobilisation<\/strong><\/p>\n<ul>\n<li>What\u2019s new: Despite the inclusion of new recent studies, there were no new findings. Recommendation (not changed):<\/li>\n<li>Use of functional support and exercise therapy is preferred as it provides better outcomes compared with immobilisation. If immobilisation is applied to treat pain or oedema, it should be for a maximum of 10 days after which functional treatment should be commenced (level 2).<\/li>\n<\/ul>\n<p><strong>Functional treatment<\/strong><\/p>\n<ul>\n<li>What\u2019s new: New evidence emphasizes that the use of external supports (ie, braces) is preferred over immobilization. Additionally, the preferred time frame during which the use of external support is advised is outlined. Overall, the core message of this section remains unchanged.<\/li>\n<li>Recommendation (modified): Use of functional support for 4\u20136 weeks is preferred over immobilisation. The use of an ankle brace shows the greatest effects compared with other types of functional support (level 2).<\/li>\n<\/ul>\n<p><strong>Exercise<\/strong><\/p>\n<ul>\n<li>What\u2019s new: New evidence has become available on the specific effects of different types of exercise\/rehabilitation programmes; especially the beneficial effect of exercise therapy on preventing recurrent sprains, reducing the risk of functional instability and expediting the recovery of ankle joint function.<\/li>\n<li>Recommendation (modified): Exercise therapy should be commenced after LAS to optimise recovery of joint functionality. Whether exercise therapy should be supervised or not remains unclear due to contradictory evidence and requires further research (level 1).<\/li>\n<\/ul>\n<p><strong>Manuel mobilisation<\/strong><\/p>\n<ul>\n<li>What\u2019s new: Despite findings by the previous version of this guideline that manual mobilisation only results in short-term treatment effects, current evidence shows added value of manual mobilisation when used in combination with exercise therapy.<\/li>\n<li>Recommendation (modified): A combination with other treatment modalities, such as exercise therapy, enhances the efficacy of manual joint mobilisation and is therefore advised (level 3).<\/li>\n<\/ul>\n<p><strong>Other therapies<\/strong><\/p>\n<ul>\n<li>What\u2019s new: Acupuncture, vibration therapy and Bioptron light therapy were added to the present update. Concerning the\u00a0other identified therapies, new evidence did not change previous statements.<\/li>\n<li>Recommendation (not changed): As no strong evidence exists on the effectiveness of these treatment modalities, they are not advised in the treatment of acute LAS (level 2).<\/li>\n<\/ul>\n<p><strong>Communication between professionals<\/strong><\/p>\n<ul>\n<li>What\u2019s new: The checklist and statements from the previous version of this guideline were not subject to change. The most important factor remains communication.<\/li>\n<li>Recommendation (not changed): To refine communication between healthcare professionals involved in the treatment of patients with LAS, a communication check list is recommended<\/li>\n<\/ul>\n<p><strong>Prevention<\/strong><\/p>\n<ul>\n<li>What\u2019s new: In addition to updating the risk ratios by including new studies, a risk ratio is provided for the preventive effect of tape and brace for first-time ankle sprains. Additionally information on the effect on proprioception and adverse events was included. This new evidence did not change the previous recommendation.<\/li>\n<li>Recommendation (not changed): Both tape and brace have a role in the prevention of recurrent LAS despite limited evidence on mechanisms that leads to these beneficial effects (level 1). The choice of usage should depend on personal preferences.<\/li>\n<\/ul>\n<p>Exercise therapy<\/p>\n<ul>\n<li>What\u2019s new: More positive effects of different training programmes have become available, strengthening the recommendation of the previous guideline.<\/li>\n<li>Recommendation (not changed): For this reason, it is advised to start exercise therapy, especially in athletes, as soon as possible after the initial sprain to prevent recurrent LAS. Exercise therapy should be included into regular training activities as much as possible as home-based exercise (level 1). The preventive effect of exercise therapy for first-time LAS lacks evidence (table 6).<\/li>\n<\/ul>\n<p><img decoding=\"async\" class=\"alignnone size-full wp-image-14080\" src=\"https:\/\/andreasbjerregaard.files.wordpress.com\/2018\/07\/skc3a6rmbillede-2018-07-23-kl-19-45-22.png?w=825\" sizes=\"(max-width: 464px) 100vw, 464px\" srcset=\"https:\/\/andreasbjerregaard.files.wordpress.com\/2018\/07\/skc3a6rmbillede-2018-07-23-kl-19-45-22.png 464w, https:\/\/andreasbjerregaard.files.wordpress.com\/2018\/07\/skc3a6rmbillede-2018-07-23-kl-19-45-22.png?w=71 71w, https:\/\/andreasbjerregaard.files.wordpress.com\/2018\/07\/skc3a6rmbillede-2018-07-23-kl-19-45-22.png?w=143 143w\" alt=\"Sk\u00e6rmbillede 2018-07-23 kl. 19.45.22.png\" data-attachment-id=\"14080\" data-permalink=\"https:\/\/physioblogandreasbjerregaard.com\/2018\/07\/23\/diagnosis-treatment-and-prevention-of-ankle-sprains-update-of-an-evidence-based-clinical-guideline\/skaermbillede-2018-07-23-kl-19-45-22\/\" data-orig-file=\"https:\/\/andreasbjerregaard.files.wordpress.com\/2018\/07\/skc3a6rmbillede-2018-07-23-kl-19-45-22.png\" data-orig-size=\"464,974\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"Sk\u00e6rmbillede 2018-07-23 kl. 19.45.22\" data-image-description=\"\" data-medium-file=\"https:\/\/andreasbjerregaard.files.wordpress.com\/2018\/07\/skc3a6rmbillede-2018-07-23-kl-19-45-22.png?w=143\" data-large-file=\"https:\/\/andreasbjerregaard.files.wordpress.com\/2018\/07\/skc3a6rmbillede-2018-07-23-kl-19-45-22.png?w=464\" \/><\/p>\n<p>&nbsp;<\/p>\n<p><img decoding=\"async\" class=\"alignnone size-full wp-image-14079\" src=\"https:\/\/andreasbjerregaard.files.wordpress.com\/2018\/07\/skc3a6rmbillede-2018-07-23-kl-19-44-23.png?w=825\" sizes=\"(max-width: 684px) 100vw, 684px\" srcset=\"https:\/\/andreasbjerregaard.files.wordpress.com\/2018\/07\/skc3a6rmbillede-2018-07-23-kl-19-44-23.png 684w, https:\/\/andreasbjerregaard.files.wordpress.com\/2018\/07\/skc3a6rmbillede-2018-07-23-kl-19-44-23.png?w=136 136w, https:\/\/andreasbjerregaard.files.wordpress.com\/2018\/07\/skc3a6rmbillede-2018-07-23-kl-19-44-23.png?w=271 271w\" alt=\"Sk\u00e6rmbillede 2018-07-23 kl. 19.44.23.png\" data-attachment-id=\"14079\" data-permalink=\"https:\/\/physioblogandreasbjerregaard.com\/2018\/07\/23\/diagnosis-treatment-and-prevention-of-ankle-sprains-update-of-an-evidence-based-clinical-guideline\/skaermbillede-2018-07-23-kl-19-44-23\/\" data-orig-file=\"https:\/\/andreasbjerregaard.files.wordpress.com\/2018\/07\/skc3a6rmbillede-2018-07-23-kl-19-44-23.png\" data-orig-size=\"684,756\" data-comments-opened=\"1\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"Sk\u00e6rmbillede 2018-07-23 kl. 19.44.23\" data-image-description=\"\" data-medium-file=\"https:\/\/andreasbjerregaard.files.wordpress.com\/2018\/07\/skc3a6rmbillede-2018-07-23-kl-19-44-23.png?w=271\" data-large-file=\"https:\/\/andreasbjerregaard.files.wordpress.com\/2018\/07\/skc3a6rmbillede-2018-07-23-kl-19-44-23.png?w=684\" \/><\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Diagnosis, treatment and prevention of ankle sprains: update of an evidence-based clinical\u00a0guideline What A lateral ankle sprain (LAS) is a frequently incurred musculoskeletal injury.\u00a0A large proportion of individuals who sustain a LAS will develop chronic ankle instability (CAI).\u00a0CAI may be defined as persistent complaints of pain, swelling\u00a0and\/or giving way in combination with recurrent sprains for at least 12 months after the initial ankle sprain. Inclusion\u00a0and exclusion criteria Inclusion if they included individuals aged at least 16 years with acute LAS. Studies published in Dutch, English, German, French, Spanish, Danish or Swedish were all eligible for inclusion. Narrative reviews, case reports and cadaveric analyses were excluded. Additional exclusion criteria were reported medial ankle involvement, fractures or other concomitant injuries\/pathology and CAI. Results RICE What\u2019s new: No new statements could be made based on the newly identified studies. The increased evidence indicates that the individual aspects of RICE are not effective, apart from cryotherapy, if provided in combination with exercise therapy. Recommendation (modified): There is no evidence that RICE alone, or cryotherapy, or compression therapy alone has any positive influence on pain, swelling or patient function. Therefore, there is no role for RICE alone in the treatment of acute LAS (level 2) (based on 33 randomized controlled trials (RCTs), n=2337) NSAID What\u2019s new: Based on the search results concerning treatment, the committee agreed on implementing a topic on NSAIDs. Over the past years much research has been undertaken on NSAIDs in relation to musculoskeletal injuries, and in many countries they are available without prescription. However, before recommending NSAIDs, their effect in the specific context of an ankle sprain had to be assessed. Recommendation (new): NSAIDs may be used by patients who have incurred an acute LAS for the primary purpose of reducing pain and swelling. However, care should be taken in NSAID usage as it is associated with complications (level 2) and may suppress or delay the natural healing process. Immobilisation What\u2019s new: Despite the inclusion of new recent studies, there were no new findings. Recommendation (not changed): Use of functional support and exercise therapy is preferred as it provides better outcomes compared with immobilisation. If immobilisation is applied to treat pain or oedema, it should be for a maximum of 10 days after which functional treatment should be commenced (level 2). Functional treatment What\u2019s new: New evidence emphasizes that the use of external supports (ie, braces) is preferred over immobilization. Additionally, the preferred time frame during which the use of external support is advised is outlined. Overall, the core message of this section remains unchanged. Recommendation (modified): Use of functional support for 4\u20136 weeks is preferred over immobilisation. The use of an ankle brace shows the greatest effects compared with other types of functional support (level 2). Exercise What\u2019s new: New evidence has become available on the specific effects of different types of exercise\/rehabilitation programmes; especially the beneficial effect of exercise therapy on preventing recurrent sprains, reducing the risk of functional instability and expediting the recovery of ankle joint function. Recommendation (modified): Exercise therapy should be commenced after LAS to optimise recovery of joint functionality. Whether exercise therapy should be supervised or not remains unclear due to contradictory evidence and requires further research (level 1). Manuel mobilisation What\u2019s new: Despite findings by the previous version of this guideline that manual mobilisation only results in short-term treatment effects, current evidence shows added value of manual mobilisation when used in combination with exercise therapy. Recommendation (modified): A combination with other treatment modalities, such as exercise therapy, enhances the efficacy of manual joint mobilisation and is therefore advised (level 3). Other therapies What\u2019s new: Acupuncture, vibration therapy and Bioptron light therapy were added to the present update. Concerning the\u00a0other identified therapies, new evidence did not change previous statements. Recommendation (not changed): As no strong evidence exists on the effectiveness of these treatment modalities, they are not advised in the treatment of acute LAS (level 2). Communication between professionals What\u2019s new: The checklist and statements from the previous version of this guideline were not subject to change. The most important factor remains communication. Recommendation (not changed): To refine communication between healthcare professionals involved in the treatment of patients with LAS, a communication check list is recommended Prevention What\u2019s new: In addition to updating the risk ratios by including new studies, a risk ratio is provided for the preventive effect of tape and brace for first-time ankle sprains. Additionally information on the effect on proprioception and adverse events was included. This new evidence did not change the previous recommendation. Recommendation (not changed): Both tape and brace have a role in the prevention of recurrent LAS despite limited evidence on mechanisms that leads to these beneficial effects (level 1). The choice of usage should depend on personal preferences. Exercise therapy What\u2019s new: More positive effects of different training programmes have become available, strengthening the recommendation of the previous guideline. Recommendation (not changed): For this reason, it is advised to start exercise therapy, especially in athletes, as soon as possible after the initial sprain to prevent recurrent LAS. Exercise therapy should be included into regular training activities as much as possible as home-based exercise (level 1). The preventive effect of exercise therapy for first-time LAS lacks evidence (table 6). &nbsp; &nbsp;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"postBodyCss":"","postBodyMargin":[],"postBodyPadding":[],"postBodyBackground":{"backgroundType":"classic","gradient":""},"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_wpcom_ai_launchpad_first_post":false,"_jetpack_hide_featured_image":false,"_jetpack_featured_image_duplicate_dismissed":0,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[227,2,211,190],"tags":[17,368],"class_list":["post-2395","post","type-post","status-publish","format-standard","hentry","category-ankel-sprains","category-ankle-injuries","category-injury-prevention","category-publications","tag-ankle","tag-sprains"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":7}},"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.3 - aioseo.com -->\n\t<meta name=\"description\" content=\"Diagnosis, treatment and prevention of ankle sprains: update of an evidence-based clinical guideline What A lateral ankle sprain (LAS) is a frequently incurred musculoskeletal injury. 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A large proportion of individuals who sustain a LAS will develop chronic ankle instability (CAI). CAI may be defined as persistent complaints of pain, swelling and\/or giving way in combination with recurrent sprains for\" \/>\n\t\t<meta property=\"og:url\" content=\"https:\/\/andreasphysioblog.com\/?p=2395\" \/>\n\t\t<meta property=\"article:published_time\" content=\"2018-07-23T13:14:19+00:00\" \/>\n\t\t<meta property=\"article:modified_time\" content=\"2021-06-16T20:08:01+00:00\" \/>\n\t\t<meta name=\"twitter:card\" content=\"summary\" \/>\n\t\t<meta name=\"twitter:title\" content=\"Diagnosis, treatment and prevention of ankle sprains: update of an evidence-based clinical guideline - Physioblog by Andreas Bjerregaard\" \/>\n\t\t<meta name=\"twitter:description\" content=\"Diagnosis, treatment and prevention of ankle sprains: update of an evidence-based clinical guideline What A lateral ankle sprain (LAS) is a frequently incurred musculoskeletal injury. A large proportion of individuals who sustain a LAS will develop chronic ankle instability (CAI). 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