{"id":3292,"date":"2022-10-18T16:32:25","date_gmt":"2022-10-18T16:32:25","guid":{"rendered":"https:\/\/andreasphysioblog.com\/?p=3292"},"modified":"2022-10-18T16:33:32","modified_gmt":"2022-10-18T16:33:32","slug":"3292","status":"publish","type":"post","link":"https:\/\/andreasphysioblog.com\/?p=3292","title":{"rendered":"Safety concern when using blood flow restriction (BFR)\u00a0"},"content":{"rendered":"<h1><b>Safety concern when using blood flow restriction (BFR)<\/b><span style=\"font-weight: 400;\">\u00a0<\/span><\/h1>\n<p><img fetchpriority=\"high\" decoding=\"async\" class=\"aligncenter wp-image-3303 size-full\" src=\"https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/download.jpeg\" alt=\"\" width=\"272\" height=\"185\" \/><\/p>\n<p><b>Introduction\u00a0<\/b><\/p>\n<p><span style=\"font-weight: 400;\">The objective of the blogpost is to assess the safety and potential side effects of Blood flow restriction (BFR) training clinical application to patients with early post operative conditions.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Blood flow restriction (BFR) training involves the use of cuffs placed proximally around a limb, with the aim of maintaining arterial inflow while occluding venous return during exercise (Scott et al. 2015). When combined with low-intensity resistance exercise, BFR has been reported to promote similar hypertrophy and strength gains as moderate to heavy load and lower joint forces\/stress in a manner comparable with that of high-intensity resistance exercise in healthy adults.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">At rest, cuff pressure is slowly increased until the flow of blood is no longer detected, a term frequently referred to as total limb occlusion pressure (LOP) or arterial occlusion pressure (AOP). A submaximal percentage (eg, 40%-80%) of that pressure is prescribed for the exercise session as this method allows for appropriate progression of the pressure, similar to the way progressive loading resistance training (Bond, 2018).<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Since the first publication in 1987 on the effect of BFR training (Eiken, 1987) many studies have highlighted the important role BFR training may play in rehabilitation settings to optimize recovery after surgery (Rolnick, 2021). The physiological mechanisms behind these muscle adaptations include acute muscle cell swelling, increased anabolic hormone production, altered muscle fiber-type recruitment associated with hypoxia and fatigue, decreased myostatin, decreased atrogenes, and satellite cell proliferation, increased cell signaling for pathways related to muscle protein synthesis and decreased cell signaling for pathways resulting in muscle protein breakdown (Minniti, 2019; Bond, 2018, Nascimento et al 2022).<\/span><\/p>\n<p><span style=\"font-weight: 400;\">However, there has been a concern on how safe BFR training are when introduced early after post op procedure as most studies have stringent inclusion\/exclusion criteria, leaving limited data on individuals with comorbidities frequently seen in rehabilitation clinics (Nascimento et al 2022).\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">To address this the clinician can ask (Nascimento et al 2022).:<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Is my patient like the participants in the studies with BFRT?\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Does BFRT have a clinically relevant benefit (e.g., improved function or hypertrophy) that outweighs the potential risks of application?\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Is another treatment or method available that could provide similar results with less risk than BFRT?<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">From a national survey on the safety of KAATSU training the occurrence ratio of side effects was as follows: subcutaneous hemorrhage (13.1%), numbness (1.297%), cerebral anemia (0.277%), cold feeling (0.127%), venous thrombus (0.055%), pulmonary embolism (0.008%), rhabdomyolysis (0.008%), deterioration of ischemic heart disease (0.016%) (Fig. 9 and table 1). In addition, fainting has occurred in rare cases, and hypoglycemia has been reported (Nakajima, 2006). Numbness is likely due to inappropriately high tourniquet pressures, thus resulting in peripheral nerve compression. Therefore, appropriate selection and application of the cuff (i.e., size, site, pressure) is essential for preventing peripheral nerve irritation (Vanwye et al. 2017). The most frequently used cuff width is 10 to 12 cm, although cuffs greater than 15 cm may be more desirable (Bond, 2019). Furthermore, low load BFR training with healthy individuals and older adults with heart disease found no change in blood markers for thrombin generation or intravascular clot formation (Vanwye et al. 2017).<\/span><\/p>\n<p><span style=\"font-weight: 400;\">In a recent review (Minniti, 2019) on the safety and potential adverse events related to the use of BFR in patients with musculoskeletal disorders. A large number of studies did not even address safety and therefore could not be included in this review. The majority of the RCTs that were included were conducted in patients with knee-related musculoskeletal conditions. Of the 152 patients who received BFR as an intervention, no one experienced a rare adverse event, and only 4 experienced common adverse events. These events are comparable with the adverse events seen in patients who receive traditional resistance training interventions (Minniti, 2019).\u00a0<\/span><\/p>\n<p><b>Safety concerns<\/b><\/p>\n<p><span style=\"font-weight: 400;\">It is strongly recommended to review of the patient&#8217;s medical history, the signs, and symptoms indicative of underlying disease be used to avoid undesirable. Pre-screening questions or questionnaires that are included in the documentation for a new client&#8217;s or patient&#8217;s initial evaluation might help to make some clinical decisions, while others depend on an individual and physical examination.\u00a0<\/span><\/p>\n<p><img decoding=\"async\" class=\"alignnone size-full wp-image-3304\" src=\"https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-18-at-19.31.43.png\" alt=\"\" width=\"1126\" height=\"988\" srcset=\"https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-18-at-19.31.43.png 1126w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-18-at-19.31.43-600x526.png 600w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-18-at-19.31.43-300x263.png 300w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-18-at-19.31.43-1024x899.png 1024w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-18-at-19.31.43-768x674.png 768w\" sizes=\"(max-width: 1126px) 100vw, 1126px\" \/><\/p>\n<p><span style=\"font-weight: 400;\">Three primary areas of concern relating to BFR training identified in the literature are venous thromboembolism (VTE), potentially excessive hemodynamic\/cardiovascular responses and muscle damage. Understanding what the available literature has demonstrated regarding these concerns is paramount to use of BFR safely and will assist practitioners in the manipulation of variables such as load, pressure, effort, and volume to further the safety profile (Rolnick, 2021).\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Venous thromboembolism (VTE): The concern regarding the potential for BFR to increase the risk of venous thromboembolism (VTE), which may present as deep vein thrombosis (DVT) or pulmonary embolism (PE), remains for some clinicians, especially for their postsurgical patients (Bond, 2018)<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Nascimento et al 2022 have summarizes the concerns about the use of BFRT associated with DVT development in medically compromised populations in table 1.<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">And further risk factor assessment of thrombosis in table 2<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Relevant risk factors concerning Diabetes patients before beginning BFRT in table 4.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Relevant risk factors concerning cardiovascular and hypertensive clients\/patients before BFRT in table 5.\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Risk factors concerning rheumatoid arthritis patients before BFRT in table 6.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Risk factors concerning apparently healthy individuals before BFRT in table 7.<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\"><img decoding=\"async\" class=\"alignnone size-full wp-image-3296\" src=\"https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-23.24.18.png\" alt=\"\" width=\"1122\" height=\"364\" srcset=\"https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-23.24.18.png 1122w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-23.24.18-600x195.png 600w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-23.24.18-300x97.png 300w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-23.24.18-1024x332.png 1024w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-23.24.18-768x249.png 768w\" sizes=\"(max-width: 1122px) 100vw, 1122px\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3297\" src=\"https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-23.23.52.png\" alt=\"\" width=\"1128\" height=\"996\" srcset=\"https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-23.23.52.png 1128w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-23.23.52-600x530.png 600w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-23.23.52-300x265.png 300w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-23.23.52-1024x904.png 1024w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-23.23.52-768x678.png 768w\" sizes=\"(max-width: 1128px) 100vw, 1128px\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3298\" src=\"https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-23.23.28.png\" alt=\"\" width=\"1140\" height=\"1148\" srcset=\"https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-23.23.28.png 1140w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-23.23.28-100x100.png?crop=1 100w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-23.23.28-600x604.png 600w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-23.23.28-298x300.png 298w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-23.23.28-1017x1024.png 1017w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-23.23.28-150x150.png?crop=1 150w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-23.23.28-768x773.png 768w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-23.23.28-200x200.png?crop=1 200w\" sizes=\"(max-width: 1140px) 100vw, 1140px\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3299\" src=\"https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-23.22.27.png\" alt=\"\" width=\"1128\" height=\"1240\" srcset=\"https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-23.22.27.png 1128w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-23.22.27-600x660.png 600w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-23.22.27-273x300.png 273w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-23.22.27-932x1024.png 932w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-23.22.27-768x844.png 768w\" sizes=\"(max-width: 1128px) 100vw, 1128px\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3300\" src=\"https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-23.20.10.png\" alt=\"\" width=\"1126\" height=\"1240\" srcset=\"https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-23.20.10.png 1126w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-23.20.10-600x661.png 600w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-23.20.10-272x300.png 272w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-23.20.10-930x1024.png 930w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-23.20.10-768x846.png 768w\" sizes=\"(max-width: 1126px) 100vw, 1126px\" \/> <img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3301\" src=\"https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-23.18.53.png\" alt=\"\" width=\"1676\" height=\"1348\" srcset=\"https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-23.18.53.png 1676w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-23.18.53-600x483.png 600w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-23.18.53-300x241.png 300w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-23.18.53-1024x824.png 1024w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-23.18.53-768x618.png 768w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-23.18.53-1536x1235.png 1536w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-23.18.53-1200x965.png 1200w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-23.18.53-1320x1062.png 1320w\" sizes=\"(max-width: 1676px) 100vw, 1676px\" \/><\/span><\/p>\n<p><b>Barriers for Blood Flow Restriction Pressure\u00a0<\/b><\/p>\n<p><span style=\"font-weight: 400;\">There are many different ways BFR can be used which can lead to lack of understanding of safety concern (Rolnick, 2021).<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Rolnick, 2021, have developed a clinical decision funnel for the inclusion or exclusion of use of BFR as a musculoskeletal rehabilitation framework that allows a reasoned evidence-based decision. In this funnel the physician needs to reasoning if the use of BFR is related to a loading problem or pain problem.<\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3295\" src=\"https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-22.34.23.png\" alt=\"\" width=\"1540\" height=\"1118\" srcset=\"https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-22.34.23.png 1540w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-22.34.23-600x436.png 600w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-22.34.23-300x218.png 300w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-22.34.23-1024x743.png 1024w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-22.34.23-768x558.png 768w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-22.34.23-1536x1115.png 1536w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-22.34.23-1200x871.png 1200w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-22.34.23-1320x958.png 1320w\" sizes=\"(max-width: 1540px) 100vw, 1540px\" \/><\/p>\n<p><span style=\"font-weight: 400;\">There next the physician should consider clotting considerations. One way of screening for possible contraindications related to VTE risk for patients following surgery is mentioned above. Another used flow chart for clotting consideration is demonstrated here (Rolnick, 2021).<\/span><\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3294\" src=\"https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-22.39.39.png\" alt=\"\" width=\"1536\" height=\"1210\" srcset=\"https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-22.39.39.png 1536w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-22.39.39-600x473.png 600w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-22.39.39-300x236.png 300w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-22.39.39-1024x807.png 1024w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-22.39.39-768x605.png 768w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-22.39.39-1200x945.png 1200w, https:\/\/andreasphysioblog.com\/wp-content\/uploads\/2022\/10\/Screenshot-2022-10-15-at-22.39.39-1320x1040.png 1320w\" sizes=\"(max-width: 1536px) 100vw, 1536px\" \/><\/p>\n<p><b>Take home points<\/b><\/p>\n<p><span style=\"font-weight: 400;\">Is it safe to use BFR early after surgery? Yes, however, ask yourself the three leading questions.\u00a0<\/span><\/p>\n<ul>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Is my patient like the participants in the studies with BFRT?\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Does BFRT have a clinically relevant benefit (e.g., improved function or hypertrophy) that outweighs the potential risks of application?\u00a0<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Is another treatment or method available that could provide similar results with less risk than BFRT?<\/span><\/li>\n<\/ul>\n<p><span style=\"font-weight: 400;\">Do the patient have a specific condition then use some of the above mentioned questions or flow charts.\u00a0<\/span><\/p>\n<p><span style=\"font-weight: 400;\">Here are four classic examples of early BFR after surgery. <a href=\"https:\/\/andreasphysioblog.com\/?p=3265\">Practical implementation for BFR on post op ACLR or early weight bearing restrictions after cartilage or meniscus repair in the knee joint.<\/a><\/span><\/p>\n<p><b>Reference:\u00a0<\/b><\/p>\n<ol>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Eiken O, Bjurstedt H. Dynamic exercise in man as influenced by experimental restriction of blood flow in the working muscles. Acta Physiol Scand. 1987;131(3):339-345.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Scott BR, Loenneke JP, Slattery KM, Dascombe BJ. Blood flow restricted exercise for athletes: a review of available evidence. J Sci Med Sport. 2016;19(5):360-367.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Bond CW, Hackney KJ, Brown SL, Noonan BC. Blood Flow Restriction Resistance Exercise as a Rehabilitation Modality Following Orthopaedic Surgery: A Review of Venous Thromboembolism Risk. J Orthop Sports Phys Ther. 2019<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Rolnick N, Kimbrell K, Cerqueira MS, Weatherford B, Brandner C. Perceived Barriers to Blood Flow Restriction Training. Front Rehabil Sci. 2021 Jul 8;2:697082. doi: 10.3389\/fresc.2021.697082. PMID: 36188864; PMCID: PMC9397924<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Vanwye WR, Weatherholt AM, Mikesky AE. Blood Flow Restriction Training: Implementation into Clinical Practice. Int J Exerc Sci. 2017 Sep 1;10(5):649-654. PMID: 28966705; PMCID: PMC5609669.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nascimento DDC, Rolnick N, Neto IVS, Severin R, Beal FLR. A Useful Blood Flow Restriction Training Risk Stratification for Exercise and Rehabilitation. Front Physiol. 2022 Mar 11;13:808622. doi: 10.3389\/fphys.2022.808622. PMID: 35360229; PMCID: PMC8963452.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Minniti MC, Statkevich AP, Kelly RL, Rigsby VP, Exline MM, Rhon DI, Clewley D. The Safety of Blood Flow Restriction Training as a Therapeutic Intervention for Patients With Musculoskeletal Disorders: A Systematic Review. Am J Sports Med. 2020 Jun;48(7):1773-1785. doi: 10.1177\/0363546519882652. Epub 2019 Nov 11. PMID: 31710505.<\/span><\/li>\n<li style=\"font-weight: 400;\" aria-level=\"1\"><span style=\"font-weight: 400;\">Nakajima, T., Kurano, M., Iida, H., Takano, H., Oonuma, H., Morita, T., Meguro, K., Sato, Y., &amp; Nagata, T. (2006). Use and safety of KAATSU training:Results of a national survey. International Journal of Kaatsu Training Research, 2, 5-13.<\/span><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"<p>Safety concern when using blood flow restriction (BFR)\u00a0 Introduction\u00a0 The objective of the blogpost is to assess the safety and potential side effects of Blood flow restriction (BFR) training clinical application to patients with early post operative conditions.\u00a0 Blood flow restriction (BFR) training involves the use of cuffs placed proximally around a limb, with the aim of maintaining arterial inflow while occluding venous return during exercise (Scott et al. 2015). When combined with low-intensity resistance exercise, BFR has been reported to promote similar hypertrophy and strength gains as moderate to heavy load and lower joint forces\/stress in a manner comparable with that of high-intensity resistance exercise in healthy adults.\u00a0 At rest, cuff pressure is slowly increased until the flow of blood is no longer detected, a term frequently referred to as total limb occlusion pressure (LOP) or arterial occlusion pressure (AOP). A submaximal percentage (eg, 40%-80%) of that pressure is prescribed for the exercise session as this method allows for appropriate progression of the pressure, similar to the way progressive loading resistance training (Bond, 2018). Since the first publication in 1987 on the effect of BFR training (Eiken, 1987) many studies have highlighted the important role BFR training may play in rehabilitation settings to optimize recovery after surgery (Rolnick, 2021). The physiological mechanisms behind these muscle adaptations include acute muscle cell swelling, increased anabolic hormone production, altered muscle fiber-type recruitment associated with hypoxia and fatigue, decreased myostatin, decreased atrogenes, and satellite cell proliferation, increased cell signaling for pathways related to muscle protein synthesis and decreased cell signaling for pathways resulting in muscle protein breakdown (Minniti, 2019; Bond, 2018, Nascimento et al 2022). However, there has been a concern on how safe BFR training are when introduced early after post op procedure as most studies have stringent inclusion\/exclusion criteria, leaving limited data on individuals with comorbidities frequently seen in rehabilitation clinics (Nascimento et al 2022).\u00a0 To address this the clinician can ask (Nascimento et al 2022).: Is my patient like the participants in the studies with BFRT?\u00a0 Does BFRT have a clinically relevant benefit (e.g., improved function or hypertrophy) that outweighs the potential risks of application?\u00a0 Is another treatment or method available that could provide similar results with less risk than BFRT? From a national survey on the safety of KAATSU training the occurrence ratio of side effects was as follows: subcutaneous hemorrhage (13.1%), numbness (1.297%), cerebral anemia (0.277%), cold feeling (0.127%), venous thrombus (0.055%), pulmonary embolism (0.008%), rhabdomyolysis (0.008%), deterioration of ischemic heart disease (0.016%) (Fig. 9 and table 1). In addition, fainting has occurred in rare cases, and hypoglycemia has been reported (Nakajima, 2006). Numbness is likely due to inappropriately high tourniquet pressures, thus resulting in peripheral nerve compression. Therefore, appropriate selection and application of the cuff (i.e., size, site, pressure) is essential for preventing peripheral nerve irritation (Vanwye et al. 2017). The most frequently used cuff width is 10 to 12 cm, although cuffs greater than 15 cm may be more desirable (Bond, 2019). Furthermore, low load BFR training with healthy individuals and older adults with heart disease found no change in blood markers for thrombin generation or intravascular clot formation (Vanwye et al. 2017). In a recent review (Minniti, 2019) on the safety and potential adverse events related to the use of BFR in patients with musculoskeletal disorders. A large number of studies did not even address safety and therefore could not be included in this review. The majority of the RCTs that were included were conducted in patients with knee-related musculoskeletal conditions. Of the 152 patients who received BFR as an intervention, no one experienced a rare adverse event, and only 4 experienced common adverse events. These events are comparable with the adverse events seen in patients who receive traditional resistance training interventions (Minniti, 2019).\u00a0 Safety concerns It is strongly recommended to review of the patient&#8217;s medical history, the signs, and symptoms indicative of underlying disease be used to avoid undesirable. Pre-screening questions or questionnaires that are included in the documentation for a new client&#8217;s or patient&#8217;s initial evaluation might help to make some clinical decisions, while others depend on an individual and physical examination.\u00a0 Three primary areas of concern relating to BFR training identified in the literature are venous thromboembolism (VTE), potentially excessive hemodynamic\/cardiovascular responses and muscle damage. Understanding what the available literature has demonstrated regarding these concerns is paramount to use of BFR safely and will assist practitioners in the manipulation of variables such as load, pressure, effort, and volume to further the safety profile (Rolnick, 2021).\u00a0 Venous thromboembolism (VTE): The concern regarding the potential for BFR to increase the risk of venous thromboembolism (VTE), which may present as deep vein thrombosis (DVT) or pulmonary embolism (PE), remains for some clinicians, especially for their postsurgical patients (Bond, 2018) Nascimento et al 2022 have summarizes the concerns about the use of BFRT associated with DVT development in medically compromised populations in table 1. And further risk factor assessment of thrombosis in table 2 Relevant risk factors concerning Diabetes patients before beginning BFRT in table 4. Relevant risk factors concerning cardiovascular and hypertensive clients\/patients before BFRT in table 5.\u00a0 Risk factors concerning rheumatoid arthritis patients before BFRT in table 6. Risk factors concerning apparently healthy individuals before BFRT in table 7. Barriers for Blood Flow Restriction Pressure\u00a0 There are many different ways BFR can be used which can lead to lack of understanding of safety concern (Rolnick, 2021). Rolnick, 2021, have developed a clinical decision funnel for the inclusion or exclusion of use of BFR as a musculoskeletal rehabilitation framework that allows a reasoned evidence-based decision. In this funnel the physician needs to reasoning if the use of BFR is related to a loading problem or pain problem. There next the physician should consider clotting considerations. One way of screening for possible contraindications related to VTE risk for patients following surgery is mentioned above. Another used flow chart for clotting consideration is demonstrated here (Rolnick, 2021). Take home points Is it safe to use BFR<\/p>\n","protected":false},"author":1,"featured_media":3303,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_coblocks_attr":"","_coblocks_dimensions":"","_coblocks_responsive_height":"","_coblocks_accordion_ie_support":"","om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"postBodyCss":"","postBodyMargin":[],"postBodyPadding":[],"postBodyBackground":{"backgroundType":"classic","gradient":""},"_jetpack_newsletter_access":"","_jetpack_dont_email_post_to_subs":false,"_jetpack_newsletter_tier_id":0,"_jetpack_memberships_contains_paywalled_content":false,"_wpcom_ai_launchpad_first_post":false,"_jetpack_hide_featured_image":false,"_jetpack_featured_image_duplicate_dismissed":0,"_jetpack_feature_clip_id":0,"_jetpack_memberships_contains_paid_content":false,"footnotes":"","jetpack_post_was_ever_published":false},"categories":[333],"tags":[156,334,37,358],"class_list":["post-3292","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bloodflowrestrictions","tag-acl","tag-bfr","tag-knee","tag-surgery"],"blocksy_meta":{"styles_descriptor":{"styles":{"desktop":"","tablet":"","mobile":""},"google_fonts":[],"version":7}},"aioseo_notices":[],"aioseo_head":"\n\t\t<!-- All in One SEO 5.0.5 - aioseo.com -->\n\t<meta name=\"description\" content=\"Safety concern when using blood flow restriction (BFR) Introduction The objective of the blogpost is to assess the safety and potential side effects of Blood flow restriction (BFR) training clinical application to patients with early post operative conditions. 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